1593P - Influence of baseline oxidative stress level on changes in left ventricle echocardiographic parameters in patients with breast cancer receiving anth...

Date 01 October 2012
Event ESMO Congress 2012
Session Poster presentation III
Topics Complications of Treatment
Breast Cancer
Presenter Lubos Petruzelka
Authors L. Petruzelka1, M. Kocik2, M. Zimovjanova3, J. Kodytkova4, L. Vavrova4, O. Mestek5, K. Gorican2, A. Zak6
  • 1Clinic Od Oncology, First Faculty of Medicine Charles University, 12808 - Prague/CZ
  • 24thdepartment Of Internal Medicine, First Medical Faculty Charles University, 12808 - Prague/CZ
  • 3Oncology, First Faculty of Medicine Charles University, 12808 - Prague/CZ
  • 4Institute For Clinical Biochemistry And Laboratory Diagnostics, First Medical Faculty Charles University, 12808 - Prague/CZ
  • 5Department Of Analytical Chemistry, Institute of Chemical Technology, Prague/CZ
  • 64st Department Of Internal Medicine, First Medical Faculty Charles University, 128 08 - Prague/CZ

Abstract

Introduction

Breast cancer (BC), like other malignancies, is associated with chronic increase of oxidative stress (OS). Anthracyclines (ANTS), potent inductors of OS, represent first-line therapy of advanced BC. OS induction by ANTS is believed to be the key factor in ANTS- related left ventricle dysfunction and the subsequent development of heart failure, which are major complications of ANTS therapy. The aim of the present study is to establish the role of malignancy-related OS present before ANTS therapy in the development of changes in echocardiografic (ECHO) parameters after chemotherapy in patients with breast cancer.

Patients and methods

The study population consists of 99 adult female suffering from breast cancer (mean age 52 ± 12 years) receiving ANTS chemotherapy. Catalase (CAT) activity as a surrogate marker of OS level and ECHO examination were established at the baseline in all patients. Follow-up ECHO examinations were performed at the end of therapy and again one year after the start of therapy. The correlations between baseline CAT activities and changes in ECHO parameters were evaluated.

Results

Statistically significant correlation between baseline CAT activity and unfavorable change in end-diastolic left ventricle diameter ( r = 0.24; p = 0.02) was observed soon after the ANTS therapy. Statistically significant correlation between baseline CAT activities and unfavorable change in end-diastolic left ventricle diameter (r = 0.30;p = 0.003) was found at one year following the start of ANTS therapy.

Conclusion

The results of our study suggest a possible correlation between baseline OS level and the future development of morphological cardiac changes after ANTS chemotherapy in patients with breast cancer. Whether pre-treatment levels of OS can predict ANTS induced left ventricle dysfunction and/or the development of heart failure will be shown by a further follow-up of the study population. The study was supported by the grant awarded by Ministry of Health, Czech republic, IGA MZ ĆR NS 9774-4

Disclosure

All authors have declared no conflicts of interest.