763 - Epidemiological data of patients with gastric cancer in Mexico

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Gastric Cancer
Cancer Aetiology, Epidemiology, Prevention
Presenter German Ruiz
Authors G.C. Ruiz1, N. Reynoso1, C. Diaz1, E. Ruiz1, E. Trejo1, A. Mohar-Betancourt2
  • 1Medical Oncology, Instituto Nacional de Cancerologia, 14080 - Mexico City/MX
  • 2Biomedical Research, Instituto Nacional de Cancerología (INCan), Mexico City/MX

Abstract

Introduction

The gastric cancer is very common neaplasm in Asia and Central and SouthAmerica. With large differences among patients diagnosed and treated in Europe, America and Asia. We present some epidemiological data of patients with gastric cancer.

Methods

Methodology was analyzed the database of all patients diagnosed of adenocarcinoma of the stomach from January 1999 to December 2011 served in the Medical Oncology service.

Results

We identified 1179 patients evaluated by Medical Oncology, these 1130 with histology adenocarcinoma, 40 with stromal tumor gastro-intestinal, 3 with leiomiosarcoma, 3 with scamous cell and 3 with neuroendocrine tumor. Of the cases with adenocarcinoma, 56% were men with a mean age of 55.8 years +/- 13.6 and 44% occured in women with a mean age of 52.2 years +/- 13.4 (p < 0.0001). The 17.5% is presented in patients with 40 years o less. The more common histologic subtipe is diffuse in 54% versus 30% intestinal y 5% mixed (in 11% non- determinate). In patients with diffuse type-adenocarcinoma 88% are poorly differentiated and 72% with signet ring cells. Gender difference was no observed, but in relation to age, for patients under 40 years 72% is diffuse versus 40% in over 40 years (p < 0.0001). The location of the tumor is in the stomach in 86% of the cases versus 14% in the esophago-gastric junction, noting a significant difference in relation to sex, with 8.6% in women versus 18% in men (p < 0.0001). The stages were: 33 cases (2.8%) stage I, 34 cases (2.9%) stage II, 103 patients (8.7%) stage III, 194 cases (18.8%) with disease locally advanced, non-surgical and 766 patients (68.0%) stage IV. Of the patients with stage IV, 18% was confirmed by surgical and histological findings or T4 or N3, M0 (AJCC 6th edition). The most common sites of metastases are the peritoneum/ascitis in 58%, liver 26%, retroperitoneal 13%, ovarian 9.6% and lung 7.3%.

Conclusions

Gastric cancer in Mexico is a serious health problem, is diagnosed in young patients with poor prognostic factors as the diffuse histological type, poorly differentiated and signet-ring cells. The location of the tumor in esophago-gastric junction is more common in men. The diagnosis in made in most patients in advanced stages (III-IV).

Disclosure

All authors have declared no conflicts of interest.