884 - Does the finding of prostatic malignancy at radical cistectomy for bladder cancer affect prognosis?

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Urothelial Cancers
Surgery and/or Radiotherapy of Cancer
Presenter Enrica Paze
Authors E. Paze, F. Brusa, L. Ciuffreda, I. Chiappino
  • Oncologia Medica 1, Azienda Ospedaliera Universitaria S. Giovanni Battista - Molinette, 10126 - Torino/IT

Abstract

Radical surgery for muscle invasive male bladder cancer includes prostatectomy. It is not rare to find incidental prostate carcinoma at histological examination. Whether the two diseases have any relationship and if this finding may affect survival in this subset of patients is not well known. We reviewed histological reports in a series of 110 patients who underwent radical cystectomy for bladder cancer and were seen at our Institution between 2005 and 2009. Prostate tissue was found to harbour adenocarcinoma in 42 cases, prostatic intraepithelial neoplasia (PIN) in 24 cases and benign prostatic hyperplasia, prostatitis or normal findings in the remaining 44 case. Incidental prostate adenocarcinomas were between pT1a and pT3b, with Gleason scores between 5 and 9. High grade PIN was found in 18 patients and low grade in 6 pts. We compared patient and disease characteristics in these 3 groups of patients, and the results are shown in the table.

Conclusions

although based on a small number of patients we did not notice any difference among patients with and without prostatic malignancy undergoing surgery with curative intent for bladder cancer. 3 and 5 yrs overall survival does not seem to be different among the three groups of patients.

Table: 884

No malignancy PIN Adenocarcinoma
Patients age - mean - median (range) 68 yrs 71 yrs (37-85) 66 yrs 66 yrs (51-82) 70 yrs 70 yrs (57-84)
Bladder cancer: - stage I-II - stage III-IV 12 pts (27%) 32 pts (73%) 9 pts (38%) 15 pts (63%) 15 pts (36%) 27 pts (64%)
Perioperative treatment for bladder cancer 5 / 35 pts (4 pts unknown) 9/19 pts (5 pts unknown) 10/39 pts (3 pts unknown)
Perineural and/or lymphovascular invasion 17/43 pts (1 unknown) 8/24 pts 13/39 pts (3 unknown)
Positive margins after cystectomy 3 pts 5 pts 2 pts
3 yrs overall survival (CI 95%) 41.6% (24.8-58.4%) 77.2% (57.3-97.0%) 65.6% (48.6-82.7%)
5 yrs overall survival (CI 95%) 41.6% (24.8-58.4%) 57.9% (21.9-93.8%) 65.6% (48.6-82.7%)

Disclosure

All authors have declared no conflicts of interest.