162P - Determination of frequency of occurrence of the virus associated non-Hodgkins lymphoma (NHL) in different age aspects

Date 30 September 2012
Event ESMO Congress 2012
Session Poster presentation II
Topics Basic Science
Lymphomas
Presenter Sarbinaz Abdiganieva
Authors S.R. Abdiganieva, D.A. Pulatov, J.M. Ibragimov, D.A. Abdurakhmanov, K.K. Tuydjanova
  • Chemotherapy, National Cancer Research Center, 100174 - Thashkent/UZ

Abstract

NHL is often characterized by unpredictable clinical course, i.e. patients with the same disease stage, morphology, and treatments for this disease can be dramatically different. As a consequence, one can remain latent for many years, and others, on the contrary, rapidly progressing incurable with the spread of the disease. One possible reason for the unexpected course of the disease may be the viral infection. It should be noted that such information on the epidemiology of the virus infection in the NHL, both scientific and practical information is completely absent. Therefore, no evidence of a viral effect of various agents on the clinical course of the NHL, are likely to evaluate the contribution to the pathogenesis and in the future to develop new approaches to its treatment. The purpose of this research is to study the virus infection in patients with NHL using molecular-biological methods of determining the frequency depending on the age of the patients. The object of the study served the lymph nodes of 27 patients: 20men (65%) and 7 women (35%). To detect infection analysis used immunoglobulin genes by PCR diagnostic of human papillomavirus general (HPVG), herpes simplex virus I + II (HSV I + II), cytomegalovirus (CMV). Analysis of the frequency of common virus infection in different age groups showed the presence of two peaks in patients aged 18 to 35years (HPVG-37,7%, HSV I + II-19, 1%, CMV-13, 9) and 65-78 years(HPVG-30,7%, HSV I + II-29, 1%, CMV-17, 5). In the other age periods were detected less frequently: 36-45 years (HPVG-23.4%, HSV I + II-12, 1%, CMV-11, 9), 46-55 (HPVG-30.1%, HSV I + II-171%, CMV-10, 9), with the lowest frequency in the age of 56-64 years (HPVG-17,7%, HSV I + II-11, 1%, CMV-11, 9). From these, the total extent of infection by age of patients was as follows: a high degree of infection ranged in age from 18 to 35 years (97.2%) and over 65-78 years (86.7%), moderate - 46-55 years(71.7%), low infection rates, 36-45 years (53.5%) and 56-64 years(54.5%). Thus, in our study, the presence of a virus associated NHL revealed in all cases, with a statistically significant increase in the frequency of occurrence of 18 to 44 years and over 65 years. Our evidence suggests that virus infection may play an important role in the pathogenesis of NHL, and the choice of treatment effectiveness and prognosis.

Disclosure

All authors have declared no conflicts of interest.