290P - Brown fat seen on FDG PET/CT is increased in breast cancer patients compared to their age- and weight-matched controls with other cancers

Date 01 October 2012
Event ESMO Congress 2012
Session Poster presentation III
Topics Breast Cancer, Early Stage
Presenter Katherine H. Tkaczuk
Authors K.H.R. Tkaczuk1, Q. Cao2, L. Jones1, M. Smith2, S. Chumsri1, J. Jenkins2, V. Dilsizian2, W. Chen2
  • 1Medicine, University of Maryland Greenebaum Cancer Center, 21201-1595 - Baltimore/US
  • 2Radiology, University of Maryland, 21201 - Baltimore/US

Abstract

Purpose

We previously found increased brown fat deposits in mammary tissue of Rrca1 mutant breast cancer mouse models suggesting a potential role of brown fat environment in the early breast tumorigenesis. The goal of the current human study is to test the hypothesis that the prevalence of brown fat activity seen on FDG PET/CT is increased in breast cancer (BC) patients.

Methods

We conducted a retrospective study to assess the distribution and intensity of brown fat activity on FDG PET/CT in female BC patients compared to age- and weight-matched control subjects with other cancers mostly colon cancer. We analyzed 124 FDG PET/CT scans of BC patients done at the University of Maryland and 124 age- and weight-matched control subjects who had FDG PET/CT scan on the same day for staging of other cancers (the majority were colon cancer).

Results

The prevalence of brown fat was higher in BC (12.9% or 16/124) than in their age- and weight-matched control subjects (5.6% or 7/124) (p < 0.05). When the data was stratified by age, among those who were ≤ 50 years old, the prevalence of brown fat was 35.5% (11/31) in BC patients versus 9.1% (3/33) in the controls (p<0.05). In contrast, among those who were > 50 years of age, there was no difference in brown fat prevalence between BC patients and controls (5.4% or 5/93 vs 4.4% or 4/91; p = NS), respectively. Brown fat was more commonly identified in the bilateral supraclavicular regions in BC patients than controls (22 vs 6, p = 0.049). There was no difference in the intensity of brown fat between the 2 groups (mean SUV max = 3.5 ± 1.5 in BC vs 3.4 ± 0.7 in controls, p = NS).

Conclusion

The prevalence of brown fat seen on FDG PET/CT is increased in BC patients compared to their age- and weight-matched controls with other cancers, particularly in patients aged <= 50, and in the supraclavicular region. These clinical data provide further support to the experimental studies that brown fat may play a role in breast cancer tumorigenesis.

Disclosure

All authors have declared no conflicts of interest.