1011 - Borderline tumors of the ovary: 19 years experience from a tertiary center in South India

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Ovarian Cancer
Presenter Kalaichelvi Kannan
Authors K. Kannan1, N. Sridharan2, R. Pourrli Neelakantan2
  • 1Madras Medical College, 600035 - Chennai/IN
  • 2Medical Oncology, Madras Medical College, 600003 - chennai/IN

Abstract

Introduction

Borderline tumours of the ovary are neoplasms of low malignant potential (LMP) and constitute 10-15% of all epithelial ovarian cancers. This retrospective analysis was done to determine the outcome of patients with LMP tumours treated at our institution.

Methods and results

Data was collected from the department master records which were updated at every patient visit. Between 1993 and 2008, 68 patients were diagnosed with LMP tumours of ovary. The median age at presentation was 39.8 years. Sixty percent of patients were post menopausal. Eight patients presented with infertility (11.7%). Ascites was present in 50% of patients. Forty nine patients underwent radical surgery (72%) and 19 patients had fertility sparing surgery (FSS) (28%). Mucinous tumours were seen in 39 patients (57.3%), serous in 25 patients (36.7%), Brenner tumour in three (4.4%) and endometroid tumour in one patient (1.4%). Fifty five patients presented in FIGO stage I (80%) and 13 patients in stage III (20%). Micropapillary serous tumours were seen in eight patients (11.7%), invasive peritoneal implants in five patients (7.3%) and microinvasion in four patients (5.8%). Seven patients underwent chemotherapy post operatively. The median overall survival (OS) was 178 months and the median progression free survival (PFS) was 175 months. Micropapillary serous tumours, invasive peritoneal implants, microinvasion, suboptimal surgery and advanced stage were found to be poor prognostic factors for PFS and OS on univariate analysis. Recurrence was seen in seven patients of whom five patients died of progressive disease. Eighteen patients are on follow up and are free from disease. There was no difference in outcome between patients who underwent radical surgery and FSS (p = 0.11). Seven out of eight patients who had infertility at diagnosis were able to conceive and deliver normally after treatment.

Conclusion

Borderline ovarian tumours have an excellent prognosis. Fertility sparing surgery is a feasible option in these patients and is compatible with a favourable long term outcome.

Disclosure

All authors have declared no conflicts of interest.