248O - Analysis of correlation between weight at diagnosis, weight gain after breast cancer treatment and recurrence in women with early stage breast cance...
|Date||30 September 2012|
|Event||ESMO Congress 2012|
|Session||Breast cancer, early stage|
|Topics|| Breast Cancer, Early Stage
Cancer Aetiology, Epidemiology, Prevention
P. Fedele1, A. Nacci2, A.M. Lapolla1, L. Orlando1, P. Schiavone1, A. Marino3, M. Cinefra1, A. Ardizzone1, M. De Pasquale1, S. Cinieri1
Overweight at the time of EBC diagnosis has been linked frequently to poorer survival in most studies and some evidence suggests that women who gain weight after breast cancer diagnosis are at increased risk of cancer recurrence and death. Most previous studies on this topic have relied on retrospective chart reviews. The aim of this prospective, observational, single-center study is to determine whether weight at diagnosis and weight gain after EBC treatment are predictive of BC recurrence.Methods
From August 1997 to March 2012, the study included a total of 520 EBC patients (stage I-IIIa). We assessed weight and body mass index (BMI = kg/m2) at baseline (≤ 1 month after surgery) and 24 months after completion of treatment (chemotherapy ± radiotherapy). The chi square test (X2) was conducted to determine if a significant correlation exists between BC recurrence and 3 categories of BMI at diagnosis (lean weight: BMI <25; overweight: BMI 25-30; obese: BMI >25) and BC recurrence and weight changes after EBC treatment (loss of <1 kg/m2; loss of ≥ 1 kg/m2; gain of <2kg/m2; gain of >2 kg/m2).Results
Median age was 55 years (range 28-81); 58% of patients were postmenopausal, stage I-II in 89%; ER + /PGR+ in 69%; ER-/PGR- in 20%; HER2+ in 20%; 72% underwent conservative surgery + radiotherapy; 57% received chemotherapy (CT) and 78% received endocrine therapy alone or after CT. Median BMI at diagnosis was 26.8, after treatment 27.7. After a median follow up of 13 years 194 patients recurred. Statistical analysis is reported in table 1.
|Body Mass Index|
|At diagnosis||Changes after BC treatment|
|<25 kg/m2||25-30 kg/m2||>30 kg/m2||Loss >1 kg/m2||Loss <1 kg/m2||Gain <2 kg/m2||Gain >2 kg/m2|
|No of patients||179||184||157||64||32||185||145|
Our findings show that EBC patients gain weight after treatment. A significant correlation was found between weight gain after EBC treatment and recurrence, suggesting that women who gain weight after breast cancer diagnosis may be at increased risk of poor outcomes.Disclosure
All authors have declared no conflicts of interest.