18PD_PR - Optimal screening interval for detection of newly developed lung cancer: Comparison of sexual difference

Date 06 May 2017
Event ELCC 2017
Session Epidemiology and innovations in biomarker development
Topics Cancer Aetiology, Epidemiology, Prevention
Lung and other Thoracic Tumours
Presenter Mi Young Kim
Citation Annals of Oncology (2017) 28 (suppl_2): ii6-ii8. 10.1093/annonc/mdx087
Authors M.Y. Kim1, C.H. Park1, H.J. Koo1, Y.R. Park2, C. Choi3
  • 1Radiology, Asan Medical Center, 05505 - Seoul/KR
  • 2Convergence Medicine, Asan Medical Center, 05505 - Seoul/KR
  • 3Pulmonary And Critical Care Medicine, Oncology, Asan Medical Center, University of Ulsan College of Medicine, 05505 - Seoul/KR

Abstract

Background

The clinical and radiologic presentation of lung cancer in women differs from men, especially in Asia. The aim of this study is to identify potential gender-related differences of newly developed lung cancer and provide the optimal CT screening intervals for the patients who are managed in the health care center.

Methods

Between January 2000 and February 2016, a total of 46,766 consecutive patients who underwent screening chest CT in Health Care Center at Asan Medical Center of Korea were retrospectively reviewed. During the study period, 282 patients (M:F=205:77) were finally diagnosed by lung cancer. Among them, lung cancers were detected by initial screening CT in 186 patients (excluded in this study), and 96 patients (M:F=85:11, age range M:F=62.7±12.9: 62.7±8.7 years, respectively) have been clinically diagnosed as newly developed lung cancers using subsequent screening CT follow-up. Using the 96 patients, CT screening intervals, stage, and pathology (with subtype and mutation) of cancers were evaluated and analyzed to find any gender-related differences.

Results

In the 96 patients, mean age is not significantly different between genders. Most of the men were smokers (74/85, 87%). Adenocarcinoma is the most common type (36/85, 42%), followed by squamous cell carcinoma (35%), small cell lung cancer (18%), and others (5%) in men. All female patients were adenocarcinoma. The mean time interval of screening CT was relatively longer in women (5.6±3.1 years) than in men (3.6±2.4 years) (p=0.02). However, lung cancer stages are significantly higher in men. Minimum CT screening interval to detect stage I lung cancer was longer in women (5 years) compared to that in men (1 year).

Conclusions

The interval of screening CT could be longer in women than men. To detect most of stage I lung cancer, a 3-year interval screening for women and 1-year interval for men are optimal in our study for minimizing radiation hazard and worry.

Clinical trial identification

Legal entity responsible for the study

None

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.