49P - Computed tomographic features of pulmonary sarcomatoid carcinoma

Date 07 May 2017
Event ELCC 2017
Session Poster Display Session
Topics Imaging, Diagnosis and Staging
Lung and other Thoracic Tumours
Presenter Monia Attia
Citation Annals of Oncology (2017) 28 (suppl_2): ii14-ii16. 10.1093/annonc/mdx086
Authors M. Attia1, K. Abdelmoula2, H. Neji3, M. Affes1, S. Hantous-Zannad1, A. Mekkaoui1, I. Baccouche1, K. Ben Miled-M'rad1
  • 1Imaging Department, Abderrahmen Mami Hospital, 2080 - Ariana/TN
  • 2Imaging, Abderrahmen Mami Hospital, Ariana/TN
  • 3Abderrahmen Mami Hospital, Ariana/TN

Abstract

Background

Pulmonary sarcomatoid carcinoma is a rare tumor. It is subdivided into 5 subtypes and representing approximately 0.4% of non-small cell lung cancer. The aim of our work is to illustrate the computed tomography (CT) features of this tumor.

Methods

This was a retrospective case series of 18 consecutive patients with a pulmonary sarcomatoid carcinoma, collected between January 2011 and December 2016. All patients had undergone a CT scan for the diagnosis, staging and therapeutic response evaluation. CT- guided percutaneous biopsy and a histological analysis were performed in all cases for the pathological confirmation.

Results

The mean age of patients was 56.8 years (range, 46-73 years). The CT appearance of the tumor was similar for all our patients: Large mass, peripheral, heterogeneous density, with massive necrotic tissue component that strongly heightened after contrast injection; tumor had a locoregional extension with parietal and bone invasion (n = 5) and a distance extension (n = 4) to the adrenal glands. Pathological examination found a pleomorphic carcinoma (n = 3), a giant cell carcinoma (n = 1) and a carcinosarcoma (n = 2). Sarcomatoid carcinoma diagnosis was increased for the remaining patients without precision of histological subtype.

Conclusions

Pulmonary sarcomatoid carcinoma seems to have CT scan characteristics that distinguish it from other non-small cell lung cancers, specifically: diagnosis size, peripheral necrosis and increased vascularization of its fleshy portion with a local aggressiveness and a high metastatic potential.

Clinical trial identification

Legal entity responsible for the study

Abderrahmen Mami Hospital

Funding

Abderrahmen Mami Hospital

Disclosure

All authors have declared no conflicts of interest.