69P - CT-Guided radiofrequency ablation of early stage NSCLC

Date 07 May 2017
Event ELCC 2017
Session Poster Display Session
Topics Non-Small-Cell Lung Cancer, Early Stage
Lung and other Thoracic Tumours
Surgery and/or Radiotherapy of Cancer
Presenter Xiaobo Zhang
Citation Annals of Oncology (2017) 28 (suppl_2): ii20-ii23. 10.1093/annonc/mdx085
Authors X. Zhang
  • Radiology Department, General Hospital of Chinese PLA, 100853 - Beijing/CN

Abstract

Background

To prospectively evaluate the safety and efficacy of radiofrequency (RF) ablation of early stage NSCLC with diameter of less than 30 mm.

Methods

Forty patients (24 men and 16 women; age range, 35–78 years; mean age, 58 years) with early stage NSCLC (40 lesions) which were conformed by biopsy were enrolled in during 2014-2016. RF ablation was performed in tumors by CT guidance, each with a diameter of less than 30 mm (mean deviation, 14 mm). Written informed consent was obtained in this prospective study that was approved by the local ethics committee. Follow-up CT scans were obtained within 48 hours after treatment and at 2 and 6months thereafter to evaluate treatment outcome and complications. Lung spirometry measurements were obtained before and 2 months after RF ablation.

Results

Forty successful RF ablation treatments were performed. The complications occured in the periprocedural period were 9 cases of minor pneumothorax and 4 cases of sputum cruentum. There were 35 lesions of reduced size, 13 lesions of stabilized lesion size, and 2 lesions of increased size on the follow-up Contrast-enhanced CT images at 6-month. There was no modification of respiratory function was found between the spirometry measurements before the treatment and 2 months after (P < 0.05).

Conclusions

RF ablation is a safe and effective method to treat early stage NSCLC with diameter of less than 30 mm. Larger studies are necessary to fully evaluate its potential combination with other treatment techniques.

Clinical trial identification

Legal entity responsible for the study

Xiaobo Zhang

Funding

The Radiology Department of Chinese PLA General Hospital

Disclosure

The author has declared no conflicts of interest.