214P - Correlation of thymoma with myasthenia gravis in ten years experience of their surgical treatment

Date 15 April 2016
Event European Lung Cancer Conference 2016 (ELCC) 2016
Session Poster lunch
Topics Thymoma and Thymic Cancer
Presenter Fatmir Caushi
Citation Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4
Authors F. Caushi1, D. Xhemalaj2, A. Kuqo3, I. Skenduli1, A. Hatibi1, H. Hafizi1, E. Bejtja1, R. Kortoci1, F. Kokiqi1, E. Shima1
  • 1Thoracic Surgery, University Hospital of Lung Disease "Shefqet Ndroqi", 12345 - Tirana/AL
  • 2Morfology, University Hospital of Lung Disease "Shefqet Ndroqi", Tirana/AL
  • 3Neurology, QSUT Mother Teresa Hospital Center. Qendra Spitalore Universitare "Nënë Tereza", Tirana/AL

Abstract

Background

Thymoma is an extremely heterogeneous group of lesions with a wide spectrum of morphologic appearances. Classifications and staging systems are set for the purpose of standardizing treatment and predicting the clinical course and prognosis of the disease. Myasthenia gravis is present at 35% of patients. The aim of this study is to find the correlation of thymoma with myasthenia gravis and to define the best approach for their treatment.

Methods

This is a retrospective study where have been observed 40 patients with thymoma that have been operated in 10 years. In both of cases was performed a total extirpation of the tumor. All the patients had undergone neurologic assessment before and after surgery. All the patients resulted with malignancy of thymoma were treated by oncologists.

Results

50% of cases with thymoma were accompanied by myasthenia gravis. In 10% of cases the syndrome of myasthenia was observed only after thymomectomy. 7.5% of cases had relapse of myasthenia gravis after the surgery. In 94% of patients who previously the surgery were diagnosed with myasthenia gravis, the clinical state of them was improved after the surgery

Conclusions

Thymoma is strongly correlated with myasthenia gravis. This higher frequency of correlation that is found comparing with other authors may be because the major part of these patients was recommended for thoracic surgery from neurologists. Neurologic assessment and additional treatment if is necessary should be performed before and after the surgery for all cases with thymoma, in order to prevent complications of myasthenia gravis.

Clinical trial identification

Legal entity responsible for the study

Fatmir Caushi

Funding

Fatmir Caushi

Disclosure

All authors have declared no conflicts of interest.