126P - Serum markers of bone remodeling in patients with advanced non-small cell lung cancer and bone metastases
|Date||28 March 2014|
|Session||Lunch and poster display session|
|Topics|| Non-Small-Cell Lung Cancer, Metastatic
|Citation||Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131|
F. Lumachi1, F. Mazza2, A. Del Conte3, G.B. Chiara4, S.M.M. Basso4
Lung cancer is the most common cause of cancer death worldwide. In the USA, there were estimated to be 246,000 new cases and 164,000 deaths in 2013. Approximately, 80 % of lung cancers are carcinomas that are classified histologically as non-small cell lung cancer (NSCLC). The efficacy control for the treatment of bone metastases in NSLCLC is difficult and usually initiated later and with longer time between treatment cycles than the restaging of visceral or soft tissue metastases. The aim of this study was to evaluate the usefulness of bone formation serum markers bone alkaline phosphatase (bALP) and osteoprotegerin (OPG), and bone resorption serum markers tartrate-resistant acid phosphatase isoform-5b (TRACP 5b), carboxy terminal cross-linked telopeptide of type I collagen (CTX), and receptor activator of nuclear factor-κ ligand (RANKL) in patients with NSCLC and bone metastases.