81O - Potentially functional single nucleotide polymorphisms in CD133 predict local recurrence and distant metastasis after radiotherapy for non-small cel...
|Date||28 March 2014|
|Session||Proffered papers 4 - SCLC and locally advanced NSCLC|
|Topics|| Non-Small-Cell Lung Cancer, Locally Advanced
|Citation||Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131|
Q. Wang1, P. Li1, H. Liu2, H. Xiong2, J. Qian2, T. Xu3, Z. Liu2, Z. Liao3, Q. Wei2
Cancer stem cells are believed to be involved in resistance to radiotherapy and chemotherapy and responsible for local recurrence and distant metastasis. We hypothesized that genetic variations in CD133 (also called PROM1), an important marker gene of cancer stem cells, affect clinical outcomes among patients with non-small cell lung cancer (NSCLC) treated with definitive radiotherapy.