81O - Potentially functional single nucleotide polymorphisms in CD133 predict local recurrence and distant metastasis after radiotherapy for non-small cel...

Date 28 March 2014
Event ELCC 2014
Session Proffered papers 4 - SCLC and locally advanced NSCLC
Topics Non-Small-Cell Lung Cancer, Locally Advanced
Translational Research
Presenter Qiming Wang
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors Q. Wang1, P. Li1, H. Liu2, H. Xiong2, J. Qian2, T. Xu3, Z. Liu2, Z. Liao3, Q. Wei2
  • 1Department Of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 450008 - Zhengzhou/CN
  • 2Departments Of Epidemiology, The University of Texas M. D. Anderson Cancer Center, 77030 - Houston/US
  • 3Departments Of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 77030 - Houston/US

Abstract

Cancer stem cells are believed to be involved in resistance to radiotherapy and chemotherapy and responsible for local recurrence and distant metastasis. We hypothesized that genetic variations in CD133 (also called PROM1), an important marker gene of cancer stem cells, affect clinical outcomes among patients with non-small cell lung cancer (NSCLC) treated with definitive radiotherapy.