73P - Investigating neuroendocrine markers of small cell lung cancer

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Small-Cell Lung Cancer
Pathology/Molecular Biology
Presenter Thomas Layton
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors T. Layton1, A. White2, S. Meredith2
  • 1Faculty Of Life Sciences, University of Manchester, OX9 3TX - Oxford/UK
  • 2Faculty Of Life Sciences, University of Manchester, Manchester/UK

Abstract

Small cell lung cancer (SCLC) is a widespread and devastating disease. SCLC tumours contain a neuroendocrine cell population that exhibit ectopic hormone production in a minority of patients. The aim of this study was to investigate a panel of neuroendocrine peptides as potential biomarkers fof SCLC, including pro-opiomelanocortin, neuron specific enolase, chromogranin A and neural-cell adhesion molecule. This study validates further investigation into the neuroendocrine phenotype in SCLC, and POMC as a potential biomarker for the disease.