131P - Intrapleural treatment with hedgehog antagonist in a rat bioluminescent model of mesothelioma recurrence

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Basic Science
Mesothelioma
Presenter Mayura Meerang
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors M. Meerang1, O. Lauk1, E. Felley-Bosco2, S. Arni1, B. Bitanihirwe1, R.A. Stahel2, W. Weder1, I. Opitz1
  • 1Division Of Thoracic Surgery, University Hospital Zurich, 8091 - Zurich/CH
  • 2Laboratory Of Molecular Oncology, University Hospital of Zurich, 8044 - Zurich/CH

Abstract

Tumor recurrence remains a challenge after complete resection of malignant pleural mesothelioma (MPM). Stem cell activation by the hedgehog pathway was detected in MPM, thus we hypothesized that the local application of a hedgehog antagonist could suppress the growth of MPM after resection. Here, we aim to use an immuno-competent rat bioluminescent MPM model to test the efficacy of local intracavitary treatment with the FDA approved hedgehog antagonist in the prevention of MPM recurrence.