48P - Curcumin induces cell cycle arrest and apoptosis by upregulating p53-inducible miR-192-5p/215 in human lung cancer

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Lung and other Thoracic Tumours
Translational Research
Presenter Jian Zhang
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors J. Zhang, M. Ye
  • Department Of Pulmonary Medicine, Xijing Hospital, Fourth Military Medical University, 710032 - Xian/CN

Abstract

Non-small cell lung cancer is one of the leading causes of cancer-related mortality world wide. The overall survival of lung cancer is far from satisfactory and it is urgent to explore more efficient and well-tolerated regimens. The medical herb Curcuma longa derived phytomedicine, curcumin, has attracted increasing interest as an anti-cancer drug. The mechanisms of action for curcumin involve multiple signaling associated with cancer. The present study highlighted curcumin can act as an epigenetic agent for miRNAs in human lung cancers.