International Prognostic Index for Agressive Non-Hodgkin's Lymphoma

The International Non-Hodgkin's Lymphoma Prognostic factor Project was undertaken to develop a model for predicting outcomes in patients with aggressive non-Hodgkin's lymphoma on the basis of the patients' clinical characteristics before treatment. Two indexes (the International Prognostic Index and age-adjusted index), were significantly more accurate than the Ann Arbor classification in predicting long-term survival.

Risk factors for the Definition of the International Prognostic Index (IPI)

General Index Parameter Age Adjusted Index
1 Age > 60 years n.a.
1 PS 2-4 1
1 Stage 3-4 1
1 LDH elevated 1
1 Extra nodal >1 site non considered
5 Maximum Score 3

Risk Groups of the International Prognostic Index

No. of Risk Factors
 
No. of Risk Factors
 
IPI Group
0 - 1 0 1 = low
2 1 2 = low intermediate
3 2 3 = high intermediate
4 - 5 3 4 = high

International Prognostic Index for Aggressive Lymphoma (General IPI)

IPI-lymphoma_02

Age adjusted International prognostic Index

IPI-ageadjusted_02

Copyright ©2008 Massachusetts Medical Society. All rights reserved. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. A Predictive Model for Aggressive Non-Hodgkin's Lymphoma.
NEJM 1993, Sept 30, 329(14): 987-994.

Last update: 07 December 2008