Colorectal Cancer: Predicted 5-Year DFS with/without 5FU-Based Adjuvant Therapy

Predicted 5-Year DFS Estimates (%) by T stage, Nodal Status, and Grade for Patients Treated With Surgery Alone and Surgery With FU-Based Adjuvant Chemotherapy

A pooled analysis of adjuvant chemotherapy trials for patients with resected colon cancer was performed to quantify the benefit of 5FU-based chemotherapy for predefined clinical and pathologic subgroups. The table below provides individualised estimates of baseline prognosis and adjuvant-therapy benefit based on T stage, nodal status and grade.

Results are presented as % patients still alive at 5 years with 95% confidence interval and group size. 

Low grade patients

Group Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T1-2 N/A N/A  
0 nodes & T3 73 - [69 - 76] 77 - [74 - 80] 4
0 nodes & T4 60 - [54 - 68] 66 - [59 - 73] 6
1-4 nodes & T1-2 62 - [56 - 70] 75 - [70 - 81] 13
1-4 nodes & T3 49 - [45 - 54] 65 - [62 - 69] 16
1-4 nodes & T4 33 - [26 - 43] 51 - [44 - 60] 18
5+ nodes & T1-2 39 - [30 - 51] 57 - [48 - 67] 18
5+ nodes & T3 24 - [19 - 31] 43 - [37 - 49] 19
5+ nodes & T4 11 - [6 - 20] 27 - [19 - 37] 16

High grade patients

Group Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T1-2 N/A N/A  
0 nodes & T3 65 - [60 - 70] 70 - [65 - 74] 5
0 nodes & T4 51 - [43 - 60] 57 - [49 - 66] 6
1-4 nodes & T1-2 53 - [44 - 63] 68 - [61 - 76] 15
1-4 nodes & T3 38 - [33 - 44] 56 - [51 - 62] 18
1-4 nodes & T4 23 - [16 - 32] 40 - [32 - 51] 17
5+ nodes & T1-2 28 - [19 - 42] 46 - [37 - 58] 18
5+ nodes & T3 15 - [10 - 22] 32 - [26 - 39] 17
5+ nodes & T4 5 - [3 - 12] 17 - [11 - 26] 12

Abbreviations

  • DFS: disease-free survival
  • 5-FU: 5-fluorouracil
  • N/A: not applicable (because of insufficient clinical data for resected T1 to T2, N0 or stage I colon cancer)

Reprinted with permission. ©2008 American Society of Clinical Oncology. All rights reserved. Gill S et al: Pooled Analysis of Fluorouracil-Based Adjuvant Therapy for Stage II and III Colon Cancer: Who Benefits and by How Much? J Clin Oncol Vol.22 (10), 2004: 1797-1806.

Last update: 07 December 2008