Colorectal Cancer: Observed 5-Year DFS with/without 5FU-Based Adjuvant Therapy

Colorectal cancer: observed 5-year DFS with/without 5FU-based adjuvant therapy

Using the end point of 5-year DFS, the model was evaluated for discriminating ability, calibration and over-fitting. The calibration of the model was assessed by comparing the predicted 5-year DFS rates for surgery alone and for surgery plus adjuvant therapy with the corresponding observed or Kaplan-Meier estimate probabilities.

Results are presented as % patients still alive at 5 years with 95% confidence interval and group size.

Low grade patients

Group Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T3 73 - [69 - 77], N=587 79 - [75 - 82], N= 597 6
0 nodes & T4 69 - [54 - 87], N= 33 72 - [58 - 89], N= 36 3
1-4 nodes & T1-2 72 - [62 - 84], N= 65 88 - [81 - 96], N= 71 16
1-4 nodes & T3 46 - [41 - 51], N= 464 64- [59 - 68], N= 496 18
1-4 nodes & T4 33 - [20 - 54], N= 37 56 - [38 - 81], N= 24 23
5+ nodes & T1-2 29 - [12 - 68], N= 14 44 - [25 - 78], N= 17 15
5+ nodes & T3 26 - [20 - 36], N= 128 48 - [40 - 57], N= 142 22
5+ nodes & T4 10 - [2 - 65], N= 10 24 - [7 - 81], N=8 14

High grade patients

Group Surgery Alone Surgery + Chemotherapy Abs. gain* (%)
0 nodes & T3 66 - [56 - 78], N= 88 62 - [51 - 75], N= 76 -4
0 nodes & T4 57 - [32 - 100], N= 10 46 - [25 - 87], N= 13 -11
1-4 nodes & T1-2 46 - [23 - 73], N= 11 72 - [47 - 100], N= 9 26
1-4 nodes & T3 52 - [43 - 64], N= 99 57 - [48 - 68], N= 95 5
1-4 nodes & T4 19 - [7 - 54], N= 20 61 - [35 - 100], N= 9 42
5+ nodes & T1-2 40 - [13 - 100], N= 6 25 - [5 - 100], N= 4 -15
5+ nodes & T3 12 - [7 - 81], N= 49 26 - [18 - 39], N= 74 14
5+ nodes & T4   39 - [18 - 85], N=10  

* Number of patients in that column averaged more than five imputed data sets.

Reprinted with permission. ©2008 American Society of Clinical Oncology. All rights reserved. Gill S et al: Pooled Analysis of Fluorouracil-Based Adjuvant Therapy for Stage II and III Colon Cancer: Who Benefits and by How Much? J Clin Oncol Vol.22 (10), 2004: 1797-1806.

Last update: 07 December 2008