Colorectal Cancer: Age-Dependent Prognosis with/without 5FU-Based Adjuvant Therapy

This table presents computed estimates for age-specific 5-year overall survival (%) in patients with resected colon cancer with/without 5FU-based adjuvant chemotherapy.

Age-Specific 5-Year OS Estimates With and Without FU-Based Adjuvant Chemotherapy

Results are presented as % patients still alive at 5 years with 95% confidence interval and group size. 

Low grade - Age group under 50 years old

Group: < 50 Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T3 83 - [80 - 86] 85 - [83 - 88] 2
0 nodes & T4 76 - [70 - 82] 79 - [74 - 84] 3
1-4 nodes & T1-2 75 - [69 - 81] 83 - [79 - 87] 8
1-4 nodes & T3 66 - [62 - 71] 76 - [73 - 80] 10
1-4 nodes & T4 54 - [46 - 64] 67 - [60 - 75] 13
5+ nodes & T1-2 53 - [44 - 65] 67 - [59 - 76] 14
5+ nodes & T3 40 - [33 - 49] 56 - [49 - 63] 16
5+ nodes & T4 26 - [18 - 39] 42 - [32 - 54] 16

Low grade - Age group 50 to 59 years old

Group: 50 to 59 Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T3 81 - [78 - 83] 83 - [81 - 86] 2
0 nodes & T4 73 [67 - 79] 76 [67 - 79] 3
1-4 nodes & T1-2 72 [66 - 78] 80 [76 - 85] 8
1-4 nodes & T3 62 [58 - 66] 73 [70 - 76] 11
1-4 nodes & T4 49 [41 - 58] 63 [56 - 70] 14
5+ nodes & T1-2 48 [39 - 60] 62 [54 - 72] 14
5+ nodes & T3 35 [29 - 42] 51 [45 - 57] 16
5+ nodes & T4 21 [14 - 33] 37 [28 - 48] 16

Low grade - Age group 60 to 69 years old

Group: 60 to 69 Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T3 79 [76 - 81] 81 [79 - 84] 2
0 nodes & T4 70 [64 - 77] 74 [68 - 80] 4
1-4 nodes & T1-2 69 [63 - 76] 78 [74 - 83] 9
1-4 nodes & T3 58 [55 - 62] 70 [67 - 74] 12
1-4 nodes & T4 45 [37 - 55] 59 [52 - 68] 14
5+ nodes & T1-2 44 [35 - 56] 59 [51 - 69] 15
5+ nodes & T3 31 [25 - 38] 47 [41 - 54] 16
5+ nodes & T4 18 [11 - 29] 33 [24 - 44] 15

Low grade - Age group 70 to 79 years old

Group: 70 to 79 Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T3 77 [74 - 80] 80 [76 - 83] 3
0 nodes & T4 67 [61 - 75] 71 [65 - 78] 4
1-4 nodes & T1-2 66 [60 - 74] 76 [71 - 82] 10
1-4 nodes & T3 55 [51 - 60] 68 [64 - 72] 13
1-4 nodes & T4 42 [33 - 52] 56 [49 - 65] 14
5+ nodes & T1-2 41 [31 - 53] 56 [47 - 67] 15
5+ nodes & T3 27 [21 - 35] 43 [37 - 51] 16
5+ nodes & T4 15 [9 - 26] 29 [20 - 41] 14

High grade - Age group under 50 years old

Group: < 50 Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T3 78 [74 - 82] 81 [77 - 85] 3
0 nodes & T4 69 [62 - 77] 72 [66 - 80] 3
1-4 nodes & T1-2 68 [60 - 76] 77 [71 - 84] 9
1-4 nodes & T3 57 [51 - 64] 69 [64 - 75] 12
1-4 nodes & T4 44 [33 - 55] 58 [50 - 68] 14
5+ nodes & T1-2 43 [32 - 57] 58 [48 - 69] 15
5+ nodes & T3 29 [22 - 39] 45 [38 - 54] 16
5+ nodes & T4 17 [10 - 29] 31 [22 - 44] 14

High grade - Age group 50 to 59 years old

Group: 50 to 59 Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T3  75 [71 - 79]  78 [74 - 82]  3
0 nodes & T4  65 [58 - 73]  69 [62 - 77]  4
1-4 nodes & T1-2  64 [56 - 72] 74 [68 - 81]   10
1-4 nodes & T3  52 [47 - 58]  65 [60 - 71]  13
1-4 nodes & T4  38 [30 - 49]  53 [45 - 63]  15
5+ nodes & T1-2  37 [27 - 51]  53 [43 - 64]  16
5+ nodes & T3  24 [18 - 32]  40 [33 - 48]  16
5+ nodes & T4  12 [7 - 23]  26 [18 - 37]  14

High grade - Age group 60 to 69 years old

Group: 60 to 69 Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T3  72 [68 - 77]  76 [71 - 80]  4
0 nodes & T4  62 [54 - 70]  66 [58 - 74]  4
1-4 nodes & T1-2  60 [52 - 70]  72 [65 - 79]  12
1-4 nodes & T3  48 [43 - 55]  62 [57 - 68]  14
1-4 nodes & T4  34 [26 - 45]  49 [41 - 60]  15
5+ nodes & T1-2  33 [23 - 47]  49 [39 - 61]  16
5+ nodes & T3  20 [15 - 28]  36 [29 - 44]  16
5+ nodes & T4  10 [41 - 60]  22 [14 - 33]  12

High grade - Age group 70 to 79 years old

Group: 70 to 79 Surgery Alone Surgery + Chemotherapy Abs. gain (%)
0 nodes & T3  70 [65 - 75]  73 [68 - 79]  3
0 nodes & T4  59 [50 - 68]  63 [55 - 72]  4
1-4 nodes & T1-2  57 [49 - 67]  69 [62 - 77]  12
1-4 nodes & T3  45 [39 - 52] 59 [53 - 65]   14
1-4 nodes & T4  31 [22 - 42]  46 [37 - 57]  15
5+ nodes & T1-2  30 [20 - 44]  45 [35 - 58]  15
5+ nodes & T3  17 [12 - 25]  32 [26 - 40]  15
5+ nodes & T4  8 [4 - 17]  19 [12 - 30]  11

Note: Clinical date not available for patients aged 80 years or older.

Abbreviations

  • OS: overall survival
  • 5-FU: 5-fluorouracil

Reprinted with permission. ©2008 American Society of Clinical Oncology. All rights reserved. Gill S et al: Pooled Analysis of Fluorouracil-Based Adjuvant Therapy for Stage II and III Colon Cancer: Who Benefits and by How Much? J Clin Oncol Vol.22 (10), 2004: 1797-1806.

Last update: 07 December 2008