General Aspects

Chapter 11 - Classification and Treatment of Paediatric Brain Tumours


Brain tumours are the most frequent solid tumours in children, accounting for approximately 20% of paediatric cancers.

Embryonal tumours and low-grade gliomas (LGGs) are more common in children, followed by high-grade glioma (HGG), brainstem glioma and ependymoma.

Specific inherited disorders lead to an increased risk of developing a brain tumour.

Clinical Presentation

Symptoms are related to age and tumour location:

  • Infants: Irritability, anorexia, open cranial sutures, failure to thrive, macrocephaly
  • Children: Headache especially upon awakening in the morning, decerebrate rigidity, head tilt, stiff neck, behavioural changes, irritability, vomiting, decreased social interactions

Revision Questions

  1. What percentage of paediatric cancers are brain tumours?
  2. To which parameters are paediatric brain tumour symptoms related?
  3. Cite three inherited disorders associated with brain tumours.

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Last update: 18 September 2017